Multi-attribute utility instruments (MAUIs) such as the EQ-5D-Y, CHU9D, HUI-2&3 and the AQoL-6D - used to assess quality-adjusted life-years (QALYs) have not been psychometrically evaluated in children/adolescents with mental disorders.
- •This study evaluated commonly used MAUIs in children/adolescents with mental disorders and compared them to frequently used non-MAUI outcome measures - both self- and clinician/parent reported.
- •The MAUIs were found to have good concurrent and construct validity when compared to self-report outcome measures but poor validity when compared to clinician or parent/guardian reported measures.
- •This research raises the question of whether QALY gains should be exclusively estimated using self-reported measures.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Publication stageIn Press Accepted Manuscript
Questionnaires used to determine quality-adjusted life-years are valid and sensitivity measures in children/adolescents with mental disorders when compared to other self-report mental health outcome measures.
Concept and design: Mihalopoulos, Chen, Scott, Allen, Coghill, Jenkins, Norman, Ratcliffe, Richardson, Viney
Acquisition of data: Mihalopoulos, Scott, Bucholc, Allen, Coghill, Jenkins
Analysis and interpretation of data: Mihalopoulos, Chen, Coghill, Jenkins, Ratcliffe, Viney
Drafting of the manuscript: Mihalopoulos, Chen, Coghill, Jenkins, Norman, Ratcliffe, Richardson, Stathis
Critical revision of the paper for important intellectual content: Mihalopoulos, Chen, Scott, Bucholc, Allen, Coghill, Norman, Ratcliffe, Stathis, Viney
Statistical analysis: Chen
Provision of study materials or patients: Bucholc, Allen, Jenkins, Stathis
Obtaining funding: Mihalopoulos, Chen, Scott, Coghill, Ratcliffe, Richardson, Viney
Administrative, technical, or logistic support: Mihalopoulos, Scott, Bucholc, Stathis
Conflict of Interest:
Dr Viney reported membership in the EuroQol Group. Dr Mihalopoulos reported being the Vice-Chair of the EuroQol Group Scientific Executive Committee. Dr Mihalopoulos also reports membership in the EuroQol Group's Valuation Working Group. Dr Mihalopoulos also reported receiving funding from EuroQol for un-related projects outside the submitted work. Dr Coghill reported receiving personal fees from Shire/Takeda, Novartis, Medice, and Servier; other from Oxford University Press and Cambridge University Press, outside the submitted work. Dr Norman is an editor for Value in Health and had no role in the peer-review process of this article. No other disclosures were reported.
Funding Support: This study was supported by a National Health and Medical Research Project (NHMRC) Project Grant, APP1105187.
Financial Disclosure: None reported
Role of Funder/Sponsor:
The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
The authors wish to thank Margaret Hoyland, Tiffany Au and the Staff of Mental Health Services in Children’s Health Queensland who assisted with data collection in the Queensland sites as well as the clinicians and staff at all recruitment sites who supported the conduct of the study.