- 1.What is already known about this topic?
Long COVID shows multiorgan symptoms and persists for a long period in some post-acute patients.
- 2.What does the paper add to existing knowledge?
Our findings highlight the temporal change in prevalence of 44 specific long COVID symptoms. About two-thirds of the symptoms did not reduce during the 1-year follow-up. The influence of acute phase-related factors for long COVID gradually decreases over time.
- 3.What insights does the paper provide for informing health care-related decision making?
Long COVID may persist longer than expected and more attention should be paid to neuropsychiatric symptoms.
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Publication stageIn Press Accepted Manuscript
These authors contributed equally to this manuscript.
Precis: The temporal changes in the prevalence and characteristics speculate that long COVID may persist longer than expected. we should pay more attention to neuropsychiatric symptoms.
Concept and design: Huang, Jia, Sun, Feng, Yang.
Acquisition of data: Jia, Sun.
Analysis and interpretation of data: Huang, Jia, Sun, Jiang, Cui, Feng, Yang.
Drafting of the manuscript: Huang.
Critical revision of the paper for important intellectual content: Feng, Yang.
Statistical analysis: Huang, Jia, Sun, Jiang, Cui.
Provision of study materials or patients: Cui.
Obtaining funding: Yang.
Administrative, technical, or logistic support: Jiang, Yang.
Supervision: Feng, Yang.
Conflict of Interest Disclosures: The authors reported no conflicts of interest.
Funding/Support: This study was funded by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2020-I2M-1-001; 2021-I2M-1-044) and China Postdoctoral Science Foundation (2021T140068).
Role of the Funder/Sponsor: The sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Acknowledgments: We thank all the individuals who generously shared their time and materials for this study. We thank the clinicians and researchers who contributed to the exploration of long COVID.