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Publication stageIn Press Accepted Manuscript
Author contributions: Conception or design of the work: D Wu, RZ Jing, ZD Yin and H Fang; Data collection: H Zheng, K He, and WZ Yu; Data analysis and interpretation: RZ Jing, H Zheng, K He, and YX Li; Drafting the article: RZ Jing; Critical revision of the article: D Wu, ZD Yin, and H Fang. Final approval of the version to be submitted: D Wu, RZ Jing, H Zheng, K He, YX Li, WZ Yu, ZD Yin, and H Fang.
●This study aims to evaluate the economic impact of DTwP and DTaP vaccination for children on the prevention of pertussis in China's 40-year immunization program.
●Without the implementation of the pertussis immunization program in China, the model estimated 115.76 million pertussis cases and 426,650 deaths in the 40 newborn cohorts.
●In the presence of the program, the number of cases and deaths of pertussis would decrease by 92.57% and 97.43%, respectively; and CNY 310,589.42 million and CNY 542,108.37 million would be averted from direct cost and societal perspective, respectively.
●The BCRs for preventing pertussis were 21.67:1 from the direct cost perspective and 20.70:1 from the societal perspective.
Conflicts of interest disclosure: The authors reported no conflicts of interest.
Support/Funding: This work was supported by the Operation of Public Health Emergency Response Mechanism of Chinese Center for Disease Control and Prevention (131031001000200001); Public Health & Disease Control and Prevention, Major Innovation & Planning Interdisciplinary Platform for the “Double-First Class” Initiative, Renmin University of China (2021PDPC); Bill & Melinda Gates Foundation (INV-034554).