A Real-World Outcome Research Study On Quality of Life, Work Productivity And Healthcare Resource Utilization In Metastatic Breast Cancer For Patients And Caregivers


      Metastatic breast cancer (mBC) represents a substantial burden for patients and their caregivers. The objective of this study was to measure utility values, activity impairment and healthcare resource utilization for mBC patients and their caregivers.


      A prospective non-interventional study was conducted in five Canadian oncology centers. Eligible patients were post-menopausal women with ER+/HER2- locally advanced or mBC. Caregivers were also invited to participate. Utility and activity impairment were assessed using the EQ-5D-5L and WPAI questionnaires, respectively. Questionnaires were completed at recruitment and at 3 and 6 months following recruitment. Results were stratified according to disease status (progression-free (PF) or progressive disease (PD)) and treatment line.


      This trial is ongoing and still recruiting. Up to now, 144 patients and 56 caregivers have been recruited. Baseline results for the first-line (1L) cohort report 39 patients in PF and 18 patients in PD, along with 14 and 8 caregivers, respectively. Results for the second- and subsequent line (≥2L) cohort report 64 patients in PF and 23 patients in PD along with 29 and 5 caregivers, respectively. Mean utility values for 1L patients in PF and PD were 0.73 (SD=0.20) and 0.62 (SD=0.21), respectively. For patients in ≥2L, mean utility values were 0.75 (SD=0.19) and 0.63 (SD=0.27) in PF and PD, respectively. Mean activity impairment for patients in 1L was 24.5% (SD=29.6) in PF and 43.3% (SD=25.9) in PD; compared to 31.7% (SD=29.7) in PF and 33.5% (SD=29.9) in PD for the 2L patient cohort. Trends were consistent among caregivers for utility values and activity impairment. Proportion of patients consulting their oncologist increased during progression, both in 1L (72.7% vs. 92.3%) and ≥2L (86.0% vs. 94.1%).


      The study demonstrates that mBC progression is associated with a utility decrement and increases in productivity loss and resource utilization for patients and caregivers.