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Research poster presentation - session III Disease-specific studies: Cardiovascular disorders – health care use & policy study| Volume 15, ISSUE 4, PA129-A130, June 01, 2012

PCV97 Real World Patient Profile of Patients with Reduced Ejection Fraction Heart Failure (HF-REF) in 5 Regions of China

      Objectives

      To characterize the real-world profile of heart failure (HF) patients with reduced ejection fraction (REF) and their treatment patterns in China.

      Methods

      A retrospective chart review was conducted in 9 hospitals in 5 key regions (Beijing, Shanghai, Wuhan, Chengdu, Guangzhou) to capture patient profiles and to evaluate treatment patterns in patients following hospitalization for HF. Patients hospitalized for HF in 2005-2008 were identified. A total of 805 HF subjects' charts were selected and reviewed for health care treatment between 2000 and 2011. Data were collected from the first HF hospitalization until the last date of data entry or death.

      Results

      A total of 460 patients with HF-REF and at least one hospitalization were followed for an average of 2.86 years. Patients were aged 61.8±14.12, and 65.9% were male. On average, HF-REF patients had 2.0±2.30 hospitalizations during follow-up. At the first hospitalization, severity was most frequently New York Heart Association (NYHA) Class III in 46.4% of patients, followed by Class IV in 27.1% and Class II in 26.0%. HF severity increased with subsequent hospitalizations. The most common etiologic/comorbid conditions were idiopathic dilated cardiomyopathy (49.3%) followed by hypertension (42.2%), atrial fibrillation (24.1%) and ischemic heart disease (20.2%). Median length of stay for the first hospitalization was 10 days with the subsequent 3 hospitalizations ranging between 8-9 days. The overall death rate during the follow-up period was 19.35% with regional variance; 0% in Shanghai to 32% in Wuhan; however Shanghai subjects had milder HF. The mean time to death was 747.0±568.9 days from first hospitalization for those who died (median: 779.0).

      Conclusions

      This large chart review provides a recent, real-world patient profile of HF-REF patients following hospitalization for HF in China. Heart failure treatment presents a large burden to the health care system in the 5 major regions in China, with some regional variations.